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R A DeFronzo Selected Research

Lipids

7/2010Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009.
10/2009Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans.
12/2008Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients.
10/2004Dysfunctional fat cells, lipotoxicity and type 2 diabetes.

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R A DeFronzo Research Topics

Disease

25Insulin Resistance
08/2015 - 02/2000
24Type 2 Diabetes Mellitus (MODY)
11/2021 - 02/2000
8Body Weight (Weight, Body)
10/2013 - 08/2000
4Weight Gain
03/2015 - 10/2011
4Glucose Intolerance
10/2013 - 09/2003
3Weight Loss (Weight Reduction)
03/2015 - 10/2011
3Obesity
08/2013 - 08/2000
2Hyperglycemia
06/2011 - 03/2001
2Atherosclerosis
07/2010 - 10/2004
1Cardiovascular Diseases (Cardiovascular Disease)
05/2016
1Myocardial Infarction
05/2016
1Stroke (Strokes)
05/2016
1Pediatric Obesity
08/2015
1Diabetes Mellitus
05/2015
1Bone Fractures (Bone Fracture)
10/2013
1Prediabetic State (Prediabetes)
10/2013
1Overweight
08/2013
1Hypoglycemia (Reactive Hypoglycemia)
03/2013
1Inflammation (Inflammations)
05/2011
1Necrosis
12/2008
1Albuminuria
12/2007
1Hyperinsulinism (Hyperinsulinemia)
05/2001

Drug/Important Bio-Agent (IBA)

21Glucose (Dextrose)FDA LinkGeneric
03/2015 - 02/2000
18Insulin (Novolin)FDA Link
08/2013 - 02/2000
9Pioglitazone (Actos)FDA Link
11/2021 - 04/2001
4Metformin (Glucophage)FDA LinkGeneric
11/2021 - 12/2006
4Exenatide (Byetta)FDA Link
11/2021 - 12/2006
4Peroxisome Proliferator-Activated Receptors (PPAR)IBA
05/2015 - 10/2004
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2013 - 12/2007
4LipidsIBA
07/2010 - 10/2004
3Hypoglycemic Agents (Hypoglycemics)IBA
11/2021 - 01/2012
3Rosiglitazone (Avandia)FDA Link
12/2008 - 12/2001
3Nonesterified Fatty Acids (NEFA)IBA
12/2008 - 12/2001
3AdiponectinIBA
12/2008 - 05/2004
2Pharmaceutical PreparationsIBA
11/2021 - 03/2015
2Insulin Glargine (Lantus)FDA Link
11/2021 - 03/2015
2Triglycerides (Triacylglycerol)IBA
08/2015 - 12/2008
2Biomarkers (Surrogate Marker)IBA
08/2015 - 05/2011
2muraglitazarIBA
05/2015 - 10/2011
2CytokinesIBA
08/2013 - 10/2004
2ThiazolidinedionesIBA
07/2010 - 10/2004
2Phosphotransferases (Kinase)IBA
07/2010 - 02/2000
2AdipokinesIBA
12/2008 - 10/2004
2C-PeptideIBA
12/2008 - 09/2003
1Glipizide (Glucotrol)FDA LinkGeneric
11/2021
1Glycated Hemoglobin (Glycosylated Hemoglobin)IBA
11/2021
1empagliflozinIBA
05/2016
1omega-Chloroacetophenone (Mace)IBA
05/2016
1HDL CholesterolIBA
08/2015
1Glucagon (Glukagon)FDA Link
08/2013
1Interleukin-6 (Interleukin 6)IBA
08/2013
1Glucagon-Like Peptide 1 (GLP 1)IBA
03/2013
1Dipeptidyl-Peptidase IV InhibitorsIBA
05/2012
1alogliptinIBA
05/2012
1ProinsulinIBA
05/2012
15'-palmitoyl cytarabine (PLAC)IBA
10/2011
1Mitogen-Activated Protein KinasesIBA
07/2010
1DiglyceridesIBA
07/2010
1CeramidesIBA
07/2010
1Acyl Coenzyme A (Acyl CoA)IBA
07/2010
1Aligeron (AS 2)IBA
03/2010
1Tissue Inhibitor of Metalloproteinase-3IBA
10/2009
1ADAM17 ProteinIBA
10/2009
1Type I Tumor Necrosis Factor ReceptorsIBA
10/2009
1PalmitatesIBA
10/2009
1LeptinIBA
12/2008
1LDL CholesterolIBA
12/2008
1PPAR-gamma AgonistsIBA
08/2007
1PPAR alphaIBA
08/2007
1IncretinsIBA
12/2006
1PPAR gammaIBA
10/2004
1ResistinIBA
06/2004
1Adiponectin ReceptorsIBA
05/2004
1Tyrosine (L-Tyrosine)FDA Link
11/2001
1Insulin Receptor Substrate ProteinsIBA
11/2001
1Insulin ReceptorIBA
11/2001
1Glycogen Synthase (Synthase I)IBA
05/2001
1Glucose Transporter Type 4IBA
05/2001
1GlycogenIBA
05/2001
1Messenger RNA (mRNA)IBA
05/2001
1HexokinaseIBA
05/2001
1VanadiumIBA
03/2001
1Hemoglobin AIBA
03/2001
1FructosamineIBA
03/2001
1vanadyl sulfateIBA
03/2001
1Bromocriptine (Parlodel)FDA LinkGeneric
08/2000
1Neurotransmitter Agents (Neurotransmitter)IBA
08/2000
1Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
02/2000

Therapy/Procedure

6Therapeutics
11/2021 - 07/2000
6Glycemic Control
03/2013 - 03/2001
1Aftercare (After-Treatment)
03/2001